MODERN EVIDENCE-BASED APPROACHES TO THE TREATMENT OF SYSTEMIC SCLERODERMA IN CHILDREN
Abstract
Systemic scleroderma (systemic sclerosis, SSc) is a rare, chronic autoimmune connective tissue disorder characterized by immune dysregulation, widespread vasculopathy, and progressive fibrosis of the skin and internal organs. Pediatric systemic sclerosis (pSSc) represents a particularly challenging subset due to its early onset, heterogeneous clinical presentation, and potential for severe organ involvement. Over the past decade, advances in understanding disease pathogenesis have led to the development of targeted therapeutic strategies. This article provides a comprehensive overview of modern, evidence-based approaches to the treatment of systemic scleroderma in children, including immunosuppressive therapy, biologic agents, antifibrotic treatments, vascular management, and hematopoietic stem cell transplantation. Emphasis is placed on individualized, multidisciplinary care and emerging therapeutic directions.
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