CLINICAL AND IMMUNOLOGICAL CHARACTERISTICS OF SYSTEMIC SCLEROSIS PATIENTS WITH ANTI-FIBRILLARIN ANTIBODIES
Abstract
Systemic sclerosis is a complex autoimmune disease characterized by immune dysregulation, vascular damage, and progressive fibrosis of the skin and internal organs. Identification of specific autoantibodies is essential for understanding disease heterogeneity and predicting clinical outcomes. Anti-fibrillarin (anti-U3-RNP) antibodies are associated with distinct clinical phenotypes and may indicate a more aggressive disease course. Investigation of their clinical relevance remains important for improving early risk stratification and personalized management of systemic sclerosis.
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