SIGNIFICANCE OF THE ASSOCIATION BETWEEN PNPLA3 GENE POLYMORPHISM AND NON-ALCOHOLIC FATTY LIVER DISEASE IN THE UZBEK POPULATION
Abstract
Global statistics indicate a steady increase in the prevalence of non-alcoholic fatty liver disease (NAFLD) across patient populations [1]. However, the absence of standardized diagnostic and screening criteria complicates the development of robust mechanisms for early diagnosis, pharmacotherapy, and prevention of this condition. NAFLD is a multifactorial disorder, the onset and progression of which are influenced by a number of interrelated factors, including genetic predisposition, age, dietary habits, lifestyle, and level of physical activity [1,2]. Genetic factors play a significant role. One of the candidate genes implicated in NAFLD pathogenesis is the PNPLA3 gene.
References
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