MIOPATIYALAR
Abstract
Mazkur maqolada miopatiyalar skelet mushak to‘qimalarining birlamchi zararlanishi bilan kechuvchi kasalliklar guruhi sifatida kompleks tahlil qilinadi. So‘nggi yillarda molekulyar genetika, immunologiya va klinik nevrologiya sohasida erishilgan yutuqlar miopatiyalar etiologiyasi va patogenezini chuqurroq anglash imkonini bermoqda. Tadqiqot doirasida irsiy shakllar, xususan, Duchenne mushak distrofiyasi kabi progressiv kechuvchi kasalliklar, shuningdek yallig‘lanishli miopatiyalar — Polimiyozit va Dermatomiyozit ning klinik-patogenetik xususiyatlari tahlil etilgan.
Maqolada mushak tolalarining degenerativ o‘zgarishlari, autoimmun mexanizmlar, fermentativ yetishmovchiliklar hamda metabolik buzilishlarning kasallik rivojlanishidagi o‘rni yoritilgan. Klinik belgilarning proksimal mushak zaifligi, harakat cheklanishi va hayot sifatiga ta’siri ilmiy manbalar asosida baholangan.
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