EFFECTIVENESS OF PLATELETS RICH PLASMA IN SKIN REJUVENATION: A SYSTEMATIC REVIEW
Abstract
A possible noninvasive method for facial rejuvenation is platelet-rich plasma (PRP). The purpose of this systematic literature review is to evaluate the type and standard of published studies assessing PRP's safety and efficacy in facial rejuvenation. A systematic review was conducted using four different databases and grey literature to collect relevant articles through a systematic search, using PRISMA guidelines. Studies on the effectiveness of PRP in facial rejuvenation were included in this review. Risk bias assessment was done using the Newcastle-Ottawa scale. Studies that met predefined criteria regarding patients, interventions, outcomes, comparator, and study design methodology were eligible for inclusion. Despite variations in research design and outcome measures, many of which were subjective, improved results were found in eleven of the twelve studies that were found, including three randomized split-face trials. To consolidate the encouraging findings of the studies found in this systematic review, more randomized controlled trials and associated systematic reviews are necessary. Level I evidence-based medicine studies are also needed to confirm the effectiveness of PRP injections in facial rejuvenation.
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