ATEROSKLEROZ RIVOJLANISHIDA MIKROORGANIZMLARNING ROLI
Abstract
Ushbu maqola ateroskleroz rivojlanishida mikroorganizmlarning o‘rni va ularning patogen mexanizmlarini yoritishga bag‘ishlangan. Tadqiqotda Helicobacter pylori, Chlamydia pneumoniae, Cytomegalovirus kabi infeksion agentlar, shuningdek ichak va og‘iz mikrobiotasidagi o‘zgarishlarning aterosklerotik jarayonlarga ta’siri tahlil qilinadi. Maqolada mikroorganizmlarning yallig‘lanishni faollashtirish, endotelial disfunksiya chaqirish, oksidlovchi stressni kuchaytirish va immun javobni o‘zgartirish orqali blyashka shakllanishida ishtirok etishi ilmiy ma’lumotlar asosida ko‘rsatib o‘tiladi. Shuningdek, mikrobiologik omillarni aterosklerozning qo‘shimcha xavf omili sifatida baholashning diagnostik va profilaktik ahamiyati haqida xulosa qilinadi.
References
1. Aramouni K, Assaf RK, Azar M, Jabbour K, Shaito A, Sahebkar A, Eid AA, Rizzo M, Eid AH. Infection with Helicobacter pylori may predispose to atherosclerosis: role of inflammation and thickening of intima-media of carotid arteries. Front Pharmacol. 2023 Oct 13;14:1285754. doi: 10.3389/fphar.2023.1285754. PMID: 37900161; PMCID: PMC10611526.
2. Ciarambino T, Crispino P, Minervini G, Giordano M. Role of Helicobacter pylori Infection in Pathogenesis, Evolution, and Complication of Atherosclerotic Plaque. Biomedicines. 2024 Feb 8;12(2):400. doi: 10.3390/biomedicines12020400. PMID: 38398002; PMCID: PMC10886498.
3. Fusco W, Adolph T, Cammarota G, Gasbarrini A, Ianiro G, Tilg H. Gut microbiota and atherosclerosis. Gut. 2025 Jul 11:gutjnl-2025-335610. doi: 10.1136/gutjnl-2025-335610. Epub ahead of print. PMID: 40645765.
4. Guo Y, Xu C, Zhang L, Chen Z, Xia X. Helicobacter pylori Infection Acts as an Independent Risk Factor for Intracranial Atherosclerosis in Women Less Than 60 Years Old. Front Cardiovasc Med. 2022 Jan 11;8:819315. doi: 10.3389/fcvm.2021.819315. PMID: 35087887; PMCID: PMC8787118.
5. Khoshbayan A, Taheri F, Moghadam MT, Chegini Z, Shariati A. The association of Chlamydia pneumoniae infection with atherosclerosis: Review and update of in vitro and animal studies. Microb Pathog. 2021 May;154:104803. doi: 10.1016/j.micpath.2021.104803. Epub 2021 Feb 17. PMID: 33609645.
6. Liang H, Lin S, Ji Y, Xiao Y, Zheng G. Helicobacter pylori increases the risk of carotid plaque formation: a clinical evidence. Ann Med. 2021 Dec;53(1):1448-1454. doi: 10.1080/07853890.2021.1927169. PMID: 34431440; PMCID: PMC8405064.
7. Libby P, Soehnlein O. Inflammation in atherosclerosis: Lessons and therapeutic implications. Immunity. 2025 Oct 14;58(10):2383-2401. doi: 10.1016/j.immuni.2025.09.012. Epub 2025 Oct 3. PMID: 41045921.
8. Otani T, Nishihira K, Azuma Y, Yamashita A, Shibata Y, Asada Y, Hatakeyama K. Chlamydia pneumoniae is Prevalent in Symptomatic Coronary Atherosclerotic Plaque Samples Obtained From Directional Coronary Atherectomy, but its Quantity is Not Associated With Plaque Instability: An Immunohistochemical and Molecular Study. Clin Pathol. 2022 Sep 26;15:2632010X221125179. doi: 10.1177/2632010X221125179. PMID: 36176379; PMCID: PMC9513565.
9. Pădureanu V, Dop D, Caragea DC, Rădulescu D, Pădureanu R, Forțofoiu MC. Cardiovascular and Neurological Diseases and Association with Helicobacter Pylori Infection-An Overview. Diagnostics (Basel). 2024 Aug 15;14(16):1781. doi: 10.3390/diagnostics14161781. PMID: 39202269; PMCID: PMC11353373.
10. Šačić D, Tomić U, Milašin J, Putnik S, Jovanović M, Radojević Škodrić S, Glumac S. The Detection of Chlamydia pneumoniae, Helicobacter pylori and Cytomegalovirus in Non-Atherosclerotic Arteries of Patients with Coronary Artery Disease. Pathogens. 2024 Oct 25;13(11):927. doi: 10.3390/pathogens13110927. PMID: 39599480; PMCID: PMC11597713.
11. Saviano A, Morabito Loprete MR, Pignataro G, Piccioni A, Gasbarrini A, Franceschi F, Candelli M. Helicobacter pylori, Atherosclerosis, and Coronary Artery Disease: A Narrative Review. Medicina (Kaunas). 2025 Feb 16;61(2):346. doi: 10.3390/medicina61020346. PMID: 40005462; PMCID: PMC11857399.
12. Tian W, Ju J, Guan B, Wang T, Zhang J, Song L, Xu H. Role of hyperhomocysteinemia in atherosclerosis: from bench to bedside. Ann Med. 2025 Dec;57(1):2457527. doi: 10.1080/07853890.2025.2457527. Epub 2025 Feb 3. PMID: 39898976; PMCID: PMC11792134.
13. Xu Z, Li J, Wang H, Xu G. Helicobacter pylori infection and atherosclerosis: is there a causal relationship? Eur J Clin Microbiol Infect Dis. 2017 Dec;36(12):2293-2301. doi: 10.1007/s10096-017-3054-0. Epub 2017 Jul 27. PMID: 28752210.
14. Zhang R, Jiang Y, Zhang G, Zeng W, Suo Y, Zhang F, Jiang X. Mitochondrial DNA in atherosclerosis: Mechanisms, biomarker potential, and therapeutic perspectives. Int Immunopharmacol. 2025 Apr 16;152:114449. doi: 10.1016/j.intimp.2025.114449. Epub 2025 Mar 11. PMID: 40073813.
15. Zhang X, Shi Y, Li T, Chang K, Gan Y, Feng Y, Zhou X. Causal association between helicobacter pylori and atherosclerosis: a two-sample Mendelian randomization. BMC Cardiovasc Disord. 2024 Mar 15;24(1):161. doi: 10.1186/s12872-024-03823-0. PMID: 38491418; PMCID: PMC10941435.
