ARCTIUM LAPPA L. O‘SIMLIGINING KIMYOVIY TARKIBI VA DORIVORLIK XUSUSIYATLARI

T. Oxunjonov

Authors

T.Oxunjonov Author

Abstract

Ushbu maqolada Arctium lappa L. (Asteraceae) — qariqiz o‘simligining dorivorlik xususiyatlari ilmiy adabiyotlar asosida tahlil qilindi. Tadqiqotning maqsadi o‘simlikning fitokimyoviy tarkibi, xususan inulin va fenol kislotalari (kafeik va xlorogen) miqdorini aniqlash hamda ularning biologik faolligi bilan bog‘liqligini yoritishdan iborat. Tadqiqot sharh-tahlil usulida olib borilib, xalqaro ilmiy manbalarda e’lon qilingan in vitro va in vivo tadqiqotlar natijalari umumlashtirildi. Natijalarga ko‘ra, A. lappa ildizida inulin miqdori quruq modda hisobida 45–60 g/100 g ni, barglarida fenol kislotalari esa 1.5–3.0 g/100 g ni tashkil etishi aniqlandi. O‘simlik ekstraktlari antioksidant, yallig‘lanishga qarshi, antimikrobial va gepatoprotektiv xususiyatlarga ega ekanligi ko‘plab tadqiqotlar bilan tasdiqlangan. Xulosa qilib aytganda, Arctium lappa biologik faol birikmalarga boy bo‘lib, uni fitopreparatlar ishlab chiqishda istiqbolli dorivor o‘simlik sifatida baholash mumkin. Kelgusida insonlarda klinik tadqiqotlar o‘tkazish zarur.

References

1. Chan, Y. S., Cheng, L. N., Wu, J. H., Chan, E., Kwan, Y. W., Lee, S. M. Y., Leung, G. P. H., & Yu, P. H. F. (2011). A review of the pharmacological effects of Arctium lappa (burdock). Inflammopharmacology, 19(5), 245–254.

2. Lin, C. C., Lin, J. M., & Yang, J. J. (1996). Anti-inflammatory and radical scavenging effects of Arctium lappa. The American Journal of Chinese Medicine, 24(2), 127–137.

3. Liu, J., Yu, H., & Zhang, L. (2014). Antioxidant activity of burdock (Arctium lappa L.) root extracts. Food Chemistry, 148, 279–284.

4. Ferracane, R., Graziani, G., Gallo, M., Fogliano, V., & Ritieni, A. (2010). Metabolic profile of the bioactive compounds of burdock (Arctium lappa) seeds, roots and leaves. Journal of Pharmaceutical and Biomedical Analysis, 51(2), 399–404.

5. Chan, Y. S., Kwan, Y. W., & Yu, P. H. F. (2010). Effect of Arctium lappa on oxidative stress and inflammation. Journal of Ethnopharmacology, 129(2), 191–197.

6. Blumenthal, M., Goldberg, A., & Brinckmann, J. (2000). Herbal Medicine: Expanded Commission E Monographs. Austin: American Botanical Council.

7. World Health Organization. (2007). WHO monographs on selected medicinal plants, Vol. 3. Geneva: WHO.

8. Duke, J. A. (2002). Handbook of Medicinal Herbs (2nd ed.). Boca Raton: CRC Press.