DIABETES MELLITUS: FROM MOLECULAR MECHANISMS TO PATHOPHYSIOLOGY AND PHARMACOLOGY

Authors

  • Mukhamedova Guzal Nadirovna Author
  • Bakhodirov Khasan Behzod ogli Author

Abstract

Diabetes mellitus is a metabolic disorder characterized by a persistent elevation of blood glucose levels, often accompanied by various long-term clinical manifestations. The disease is spreading rapidly across the globe, and its prevalence is expected to rise significantly in the coming years. This review aims to explore the mechanisms underlying the development of diabetes, its pathophysiological characteristics, and pharmacological aspects. According to the analyzed literature, diabetes mellitus is a chronic condition influenced by multiple risk factors and associated with severe complications that greatly affect patients’ quality of life. Nevertheless, advances in modern science are leading to improved methods for predicting, diagnosing, treating, and managing the different forms of this disease.

References

1. [1]Centers for Disease Control and PreventionNational Diabetes Statistics Report(November 11, 2022) https://www.cdc.gov/diabetes/pdfs/data/statistics/national-diabetes-statistics-report.pdf

2. [2]S. Thota, A. Akbar Insulin. PubMed StatPearls Publishing (2020)

https://www.ncbi.nlm.nih.gov/books/NBK560688

3. [3]M.A. Hill, Y. Yang, L. Zhang, Z. Sun, G. Jia, A.R. Parrish, et al.

Insulin resistance, cardiovascular stiffening and cardiovascular disease

Metabolism, 119 (0026-0495) (2021), Article 154766, 10.1016/j.metabol.2021.154766

4. [4]L.A. DiMeglio, C. Evans-Molina, R.A. Oram Type 1 diabetes

Lancet, 391 (10138) (2018), pp. 2449-2462 View PDFView articleView in ScopusGoogle Scholar

5. [5]American Diabetes Association Standards of medical care in diabetes—2022 abridged for primary care providers

Clin Diabetes, 40 (1) (2021), 10.2337/cd22-as01

6. [6]A.A.S. Akil, E. Yassin, A. Al-Maraghi, E. Aliyev, K. Al-Malki, K.A. Fakhro Diagnosis and treatment of type 1 diabetes at the dawn of the personalized medicine era J. Transl. Med., 19 (2021), p. 137, 10.1186/s12967-021-02778-6 View at publisher View in Scopus Google Scholar

7. [7]M. Banday, A. Sameer, S. Nissar Pathophysiology of diabetes: an overview Avicenna J. Med., 10 (4) (2020), pp. 174-188, 10.4103/ajm.ajm_53_20 View at publisher

View in ScopusGoogle Scholar

8. [8] U. Galicia-Garcia, A. Benito-Vicente, S. Jebari, A. Larrea-Sebal, H. Siddiqi, K.B. Uribe, et al.Pathophysiology of type 2 diabetes mellitus Int. J. Mol. Sci., 21 (17) (2020), p. 6275, 10.3390/ijms21176275

9. [9]I. Kyrou, C. Tsigos, C. Mavrogianni, G. Cardon, V. Van Stappen, J. Latomme, et al. Sociodemographic and lifestyle-related risk factors for identifying vulnerable groups for type 2 diabetes: a narrative review with emphasis on data from Europe

BMC Endocr. Disord., 20 (S1) (2020), p. 134, 10.1186/s12902-019-0463-3

10. [10]C.J. Bailey, C. DayTreatment of type 2 diabetes: future approaches

Br. Med. Bull., 126 (1) (2019), pp. 123-137, 10.1093/brimed/ldy013

11. [11]G. Li, T. Wei, W. Ni, A. Zhang, J. Zhang, Y. Xing, et al.

Incidence and risk factors of gestational diabetes mellitus: a prospective cohort study in Qingdao, China Front. Endocrinol., 11 (2020), . 636, 10.3389/fendo.2020.00636 View at publisherGoogle Scholar

12. [12]P. Šimják, A. Cinkajzlová, K. Anderlová, A. Pařízek, M. Mráz, M. Kršek, et al. The role of obesity and adipose tissue dysfunction in gestational diabetes mellitus J. Endocrinol., 238 (2) (2018), pp. R63-R77, 10.1530/JOE-18-0032 View at publisherView in ScopusGoogle Scholar

13. [13] Z.A. Oskovi-Kaplan, A.S. Ozgu-Erdinc Management of gestational diabetes mellitus Adv. Exp. Med. Biol., 1307 (2021), pp. 257-272, 10.1007/5584_2020_552

14. [14]H. Sun, P. Saeedi, S. Karuranga, M. Pinkepank, K. Ogurtsova, B.B. Duncan, et al.IDF diabetes Atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045

Diabetes Res. Clin. Pract., 183 (2021), Article 109119, 10.1016/j.diabres.2021.109119

15. [15]L. Szablewski Introductory chapter: glucose transporters

Intech (2020), 10.5772/intechopen.82263 Google Scholar

16. [16] R.A. Harris, J.S. Johnson Glycolysis overview. reference module in biomedical sciences Encyclopedia Biol. Chem. (2013), pp. 443-447, 10.1016/b978-0-12-801238-3.11342-x

17. [17] X. Zhang, S. Yang, J. Chen, A. Su Unraveling the regulation of hepatic gluconeogenesis Front. Endocrinol., 9 (2019), p. 802, 10.3389/fendo.2018.00802

Downloads

Published

2025-10-12