INTERACTION BETWEEN OBESITY AND GUT MICROBIOTA: NEW APPROACHES FOR DIAGNOSIS AND THERAPY

Suyunov Og‘abek Oybek o'g’li

Authors

Suyunov Og‘abek Oybek o'g’li Author

Abstract

Obesity is a serious health problem and is associated with many physiological and mental disorders, including diabetes, stroke, and depression. Gut microbiota is considered important in the development of metabolic diseases and obesity, as well as in maintaining energy homeostasis and host immunity. In recent years, scientific research has increasingly provided evidence linking obesity to the gut microbiota. Regulation of the gut microbiota is being considered as a new method of obesity treatment. However, the complex interactions among genetics, environment, gut microbiota, and obesity have not been fully elucidated

References

1. Gibson, G. R. & Roberfroid, M. B. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics.J. Nutr.125, 1401-1412 (1995).

2. Gibson, G. R. et al. The International Scientific Association for Probiotics and Prebiotics(ISAPP) consensus statement on the definition and scope of prebiotics. Nat. Rev.Gastroenterol. Hepatol. 14, 491-502 (2017).

3. Bäckhed, F., Manchester, J. K., Semenkovich, C.F. & Gordon, J. I. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc. Natl Acad. Sci. USA 104, 979-984 (2007).

4. Turnbaugh, P. J. et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 1027-1031(2006).

5. Ogden, CL • Yanovski, SZ • Carroll, MD …The epidemiology of obesity Gastroenterology. 2007;

6. Korner, J • Leibel, RI To eat or not to eat—how the gut talks to the brain N Engl J Med. 2003;

7. Hensrua, DD • Klein, S Extreme obesity: a new medical crisis in the United States Mayo Clin Proc. 2006;

8. Huda, MS . Wilding, JP . Pinkney, JH Gut peptides and the regulation of appetite Obes Rev. 2006;

9. Noor J, et al. Exploring the Impact of the Gut Microbiome on Obesity and Metabolic Health. PMC.

10. Yarahmadi A, et al. Understanding the complex function of gut microbiota: its impact on the pathogenesis of obesity and beyond: a comprehensive review. Diabetology & Metabolic Syndrome.

11. Iqbal M, et al. Unraveling the gut microbiota’s role in obesity: key metabolites. Journal of Bacteriology.