ANALYSIS OF RETINAL NERVE FIBER AND GANGLION CELL COMPLEX STATUS IN EARLY OPHTHALMOLOGICAL MANIFESTATIONS OF TYPE 2 DIABETES MELLITUS USING OPTICAL COHERENCE TOMOGRAPHY

Abdurahmonova Iroda Ikrom kizi; Odilova Guljamol Rustamovna; Yanchenko Sergey Vladimirovich

Authors

Abdurahmonova Iroda Ikrom kizi Author
Odilova Guljamol Rustamovna Author
Yanchenko Sergey Vladimirovich Author

Abstract

This scientific article is devoted to assessing the state of the retinal nerve fiber layer (RNFL) and the retinal ganglion cell complex (GCC) using optical coherence tomography (OCT) in 32 patients (64 eyes) with early ophthalmological manifestations of type 2 diabetes mellitus. The study examined the effectiveness of OCT in identifying and assessing ophthalmological changes in diabetes mellitus at an early stage. The clinical indicators of patients, RNFL and GCC measurements were analyzed, and the diagnostic value of these parameters was assessed in identifying early signs of diabetic retinopathy. The obtained results showed changes in the neural layers of the retina at an early stage, especially in the complex of ganglion cells and the thinning of the layer of nerve fibers. These data confirm the importance of using OCT in the early detection and prevention of eye diseases in patients with type 2 diabetes mellitus.

References

1. Antonetti DA, Klein R, Gardner TW. Diabetic retinopathy. New England Journal of Medicine. 2012;366(13):1227-1239.

2. Wong TY, Cheung CMG, Larsen M, Sharma S, Simo R. Diabetic retinopathy. Nature Reviews Disease Primers. 2016; 2:16012.

3. Huang D, Swanson EA, Lin CP, et al. Optical coherence tomography. Science. 1991;254(5035):1178-1181.

4. Garcia-Martin E, Satue M, Fuertes MI, et al. Retina nerve fiber layer thickness in patients with diabetes mellitus without diabetic retinopathy. Ophthalmology. 2014;121(4):748-755.

5. Lee JE, Han JW, Cho AR, et al. Ganglion cell-inner plexiform layer thickness measured by spectral-domain optical coherence tomography in patients with diabetes mellitus. Invest Ophthalmol Vis Sci. 2013;54(12):7663-7668.

6. Klein R, Knudtson MD, Lee KE, et al. The Wisconsin Epidemiologic Study of Diabetic Retinopathy XXIII. The twenty-five-year progression of retinopathy in persons with type 1 diabetes. Ophthalmology. 2008;115(11):1859-1868.

7. Sohn EH, van Dijk HW, Jiao C, et al. Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus. Proceedings of the National Academy of Sciences. 2016;113(19): E2655-E2664.

8. Simo R, Carrasco E, Garcia-Ramirez M, Hernandez C. Angiogenic and antiangiogenic factors in proliferative diabetic retinopathy. Current Diabetes Reviews. 2006;2(1):71-98.

9. Kuehn MH, Fingert JH, Kwon YH, et al. Optic nerve damage in glaucoma: An overview. Experimental Eye Research. 2005;81(5):431-438.

10. Cankaya AB, Bayramlar H, Maden A, et al. Evaluation of retinal nerve fiber layer thickness in type 2 diabetic patients without retinopathy using optical coherence tomography. Eye (Lond). 2014;28(7):880-885.

11. Early Treatment Diabetic Retinopathy Study Research Group. Photocoagulation for diabetic macular edema. Archives of Ophthalmology. 1985;103(12):1796-1806.

12. Cheung CY, Ikram MK, Sabanayagam C, Wong TY. Retinal microvasculature as a model to study the manifestations of hypertension. Hypertension. 2012;60(5):1094-1103.

13. Verma A, Raman R, Rani PK, et al. Ganglion cell-inner plexiform layer and retinal nerve fiber layer thickness measured by spectral-domain OCT in patients with diabetes. Clinical Ophthalmology. 2014; 8:2123-2132.

14. Zangwill LM, Weinreb RN, Berry CC, et al. The optical coherence tomography nerve fiber layer thickness in glaucoma. Archives of Ophthalmology. 2000;118(3):369-375.

15. Musayeva A, Vassileva S. Optical coherence tomography in diabetic retinopathy. European Journal of Ophthalmology. 2013;23(3):325-335.

16. Nakatani Y, Oshitari T, Yamamoto S. Correlation of ganglion cell complex thickness and visual field sensitivity in early diabetic retinopathy. Ophthalmologica. 2016;235(1):1-8.

17. Roy MS, Klein R, O’Colmain BJ, et al. Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study Research Group. The effect of intensive treatment of diabetes on the development and progression of diabetic retinopathy in type 1 diabetes: The DCCT/EDIC study. Ophthalmology. 2014;121(5):1013-1020.