SOME PHARMACOKINETIC PARAMETERS OF DICLOFENAC IN RHEUMATOLOGICAL PATIENTS WITH DYSBIOSIS
Abstract
The aim of the study was to study in a comparative aspect some of the pharmacokinetics of Diclofenac sodium in patients with rheumatoid arthritis with and without impaired gastric micro biocenosis (gastric dysbiosis). Materials and methods: 38 patients aged 18 to 60 years, with I-II-III degree of disease activity, were examined. In addition to the general clinical examination, an enzyme immunoassay and a urease test were performed to determine Helicobacter pylori and high-performance liquid chromatography to determine the pharmacokinetics of diclofenac. Results: the conducted studies and analysis of their results indicate that in conditions of rheumatoid arthritis, in particular, in the presence of comorbid conditions, there is a decrease in the metabolic rate and an elongation of the half-life of nonsteroidal anti-inflammatory drugs, which increases the risk of side effects, especially from the gastrointestinal tract and significantly affects the course of the disease and treatment results.
References
1. Kh, T. N., Sh, K. M., & Kurbanov, A. K. (2021). Assessment of the gastrointestinal tract in patients with rheumatoid arthritis. European Journal of Pharmaceutical and Medical Research, 2(5), 34-37.
2. Kh, T. N., Sh, K. M., & Sibirkina, M. V. (2022). Genotypical Features of Helicobacter Pylori in the Formation of Nsaid Gastropathies in Patients with Rheumatoid Arthritis. Eurasian Medical Research Periodical, 8, 94-97.
3. Tukhtaeva, N. K. (2023). The degree of damage to the gastroduodenal zone in patients with rheumatoid arthritis against the background of basic and anti-inflammatory therapy. Texas Journal of Medical Science, 25, 58-62.
4. Tukhtaeva, N. K., & Karimov, M. S. (2023). Features of helicobacter pylori genes in NSAID gastropathy in patients with rheumatoid arthritis.
5. Азадаева, К. Э., Тухтаева, Н. Х., & Каримов, М. Ш. (2023). Характеристика липидного профиля крови у больных реактивным артритом при нарушении микробиоценоза гастродуоденальной зоны и пути его коррекции.
6. Каримов, М. Ш., Тухтаева, Н. Х., & Сибиркина, М. В. (2020). Некоторые показатели фармакокинетики диклофенака натрия у больных ревматоидным артритом с учетом коморбидных состояний: научное издание. Терапевтический вестник Узбекистана / научно практический журнал: ЗАО СЕАЛ МАГ,(2), 120-125.
7. Нурметов, Х. Т., Маруфханов, Х. М., Талипов, Р. М., & Тухтаева, Н. Х. (2023). Клиникоэпидемиологические особенности анкилозирующего спондилартрита в условиях стационар.
8. Тухтаева, Н. Х., Каримов, М. Ш., & Сибиркина, М. В. (2020). Изучение обсемененности H. pylori у больных ревматоидным артритом.
