SOME PHARMACOKINETIC PARAMETERS OF DICLOFENAC IN RHEUMATOLOGICAL PATIENTS WITH DYSBIOSIS

Authors

  • Tukhtaeva Nigora Khasanova Author
  • Musayev Xasan Nosirovich Author
  • Khaydarov Ilyosbek Baxtiyarovich Author
  • Sokhibova Shakhnoza Umidjonova Author

Abstract

The aim of the study was to study in a comparative aspect some of the pharmacokinetics of Diclofenac sodium in patients with rheumatoid arthritis with and without impaired gastric micro biocenosis (gastric dysbiosis). Materials and methods: 38 patients aged 18 to 60 years, with I-II-III degree of disease activity, were examined. In addition to the general clinical examination, an enzyme immunoassay and a urease test were performed to determine Helicobacter pylori and high-performance liquid chromatography to determine the pharmacokinetics of diclofenac. Results: the conducted studies and analysis of their results indicate that in conditions of rheumatoid arthritis, in particular, in the presence of comorbid conditions, there is a decrease in the metabolic rate and an elongation of the half-life of nonsteroidal anti-inflammatory drugs, which increases the risk of side effects, especially from the gastrointestinal tract and significantly affects the course of the disease and treatment results.

References

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Published

2025-03-05