IMMUNOLOGICAL IMBALANCE AND CYTOKINE PROFILES IN SYSTEMIC SCLEROSIS: RELATIONSHIP WITH DISEASE PROGRESSION
Abstract
Systemic sclerosis (SSc) is a chronic autoimmune connective tissue disorder characterized by progressive fibrosis, microvascular injury, and immune dysregulation. The present study aimed to assess the immunological status and cytokine profile in the early stages of the disease and to determine their potential role in primary prevention strategies. A total of 20 patients with confirmed SSc were enrolled. Comprehensive analysis of immunological parameters and circulating cytokines was performed, followed by correlation with clinical manifestations and disease severity. The results revealed a pronounced imbalance in immune regulation accompanied by significant alterations in key cytokines, including IL-6, TNF-α, and TGF-β. These findings suggest that cytokine-mediated immune dysregulation plays a pivotal role in the initiation and progression of SSc. Early identification of these biomarkers may contribute to improved risk stratification, timely diagnosis, and the development of targeted preventive approaches.
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