VAKSINALAR EVOLYUTSIYASI: M-RNK VAKSINALAR VA KELAJAK
Abstract
Ushbu maqolada zamonaviy vaksina texnologiyalarining evolyutsion rivojlanish bosqichlari, xususan m-RNK platformasiga asoslangan vaksinalarning yaratilishi, ularning molekulyar ishlash mexanizmlari va immunobiologik afzalliklari tahlil qilinadi. An’anaviy jonlantirilgan yoki inaktivatsiyalangan vaksinalardan farqli ravishda, m-RNK vaksinalar antigen kodlovchi matritsali RNK molekulalari orqali hujayralarda translyatsiya jarayonini faollashtirib, tezkor va yuqori spesifik immun javob shakllanishini ta’minlaydi. Ushbu texnologiya yuqori xavfsizlik darajasi, ishlab chiqarishning qisqa sikli va virus variantlariga moslashuvchanligi bilan ajralib turadi.
References
1. Parvin, N.; Joo, S.W.; Mandal, T.K. (2024). “Enhancing Vaccine Efficacy and Stability: A Review of the Utilization of Nanoparticles in mRNA Vaccines.” Biomolecules, 14(8):1036. https://doi.org/10.3390/biom14081036
2. de Assis Burle Caldas, G., Sergio, S.A.R., Bráz, A.F. et al. (2025). “The immunogenic potential of an optimized mRNA lipid nanoparticle formulation carrying sequences from virus and protozoan antigens.”
3. Wang, Jialiang; Ding, Yaopeng; Chong, Kellie; Cui, Meng; Cao, Zeyu; Tang, Chenjue; Tian, Zhen; Hu, Yuping; Zhao, Yu; Jiang, Shaoyi. (2024). “Recent Advances in Lipid Nanoparticles and Their Safety Concerns for mRNA Delivery.” Vaccines, 12(10):1148. https://doi.org/10.3390/vaccines12101148
4. Turankar, C.C.; Kubde, J.A.; Hatwar, P.R.; Mahure, L.D. (2025). “Nano delivery Systems for mRNA: A comprehensive review of lipid based and polymer based approaches.” GSC Advanced Research and Reviews, 23(01), 062 071. https://doi.org/10.30574/gscarr.2025.23.1.0107
5. Sahu, I. et al. (2023). “Lipid nanoparticles (LNPs) for in vivo RNA delivery and their breakthrough technology for future applications.” (ScienceDirect review)
6. “A review of technological developments in lipid nanoparticle application for mRNA vaccination.” (2023) Hum Vaccin Immunother; 19(2):2256040. PMCID: PMC10503441. https://pmc.ncbi.nlm.nih.gov/articles/PMC10503441/
7. “A Comprehensive Review of mRNA Vaccines.” (2023) –
8. “Advances in lipid nanoparticle mRNA therapeutics beyond COVID-19 vaccines.” (2025)
9. Nature Reviews Materials (2021). “Lasting impact of lipid nanoparticles.” Nat Rev Mater 6, 1071. DOI: 10.1038/s41578-021-00398-6
