IMMUNOLOGICAL AND CLINICAL OVERLAP OF RHEUMATOID ARTHRITIS AND CHRONIC TONSILLITIS
Abstract
Rheumatoid arthritis is a chronic autoimmune disease primarily affecting the joints, while chronic tonsillitis involves persistent inflammation of the palatine tonsils. Emerging research suggests a significant between these two conditions, with the tonsils potentially acting as a trigger or amplifier of autoimmune responses in RA. This review explores the epidemiological, microbiological, and immunological links between chronic tonsillitis and RA, highlighting the role of tonsillar microbiota dysbiosis and the implications for diagnosis and therapeutic strategies, including tonsillectomy. This review explores the epidemiological, microbiological, and immunological links between chronic tonsillitis and RA, highlighting the role of tonsillar microbiota dysbiosis and the implications for diagnosis and therapeutic strategies, including tonsillectomy. Recent investigations within the last five years have provided deeper insights into the specific microbial mechanisms and immunological pathways involved.
References
1. J. Li et al., “The aberrant tonsillar microbiota modulates autoimmune responses in rheumatoid arthritis,” JCI Insight, vol. 9, no. 18, Aug. 2024, doi: 10.1172/jci.insight.175916.
2. J. Li et al., “Intra-genus dysbiosis of Streptococcus in tonsillar microbiota is associated with host immune features in rheumatoid arthritis,” Research Square (Research Square), Jul. 2023, doi: 10.21203/rs.3.rs-3141503/v1.
3. J. Li et al., “FRI0084 The tonsil microbiome is involved in rheumatoid arthritis,” Annals of the Rheumatic Diseases, vol. 76, p. 509, Jun. 2017, doi: 10.1136/annrheumdis-2017-eular.4707.
4. J. Li and K. A. Kuhn, “Microbial threads in the tapestry of rheumatoid arthritis,” Journal of Clinical Investigation, vol. 135, no. 18. American Society for Clinical Investigation, Sep. 15, 2025. doi: 10.1172/jci195374.
5. Y. Zhao et al., “Detection and characterization of bacterial nucleic acids in culture-negative synovial tissue and fluid samples from rheumatoid arthritis or osteoarthritis patients,” Scientific Reports, vol. 8, no. 1, Sep. 2018, doi: 10.1038/s41598-018-32675-w.
6. J. He et al., “Multidimensional profile of gut microbiota in a large cohort of stratified rheumatoid arthritis,” Research Square (Research Square), Mar. 2024, doi: 10.21203/rs.3.rs-3966115/v1.
7. M. F. Konig, “The microbiome in autoimmune rheumatic disease,” Best Practice & Research Clinical Rheumatology, vol. 34, no. 1. Elsevier BV, p. 101473, Feb. 01, 2020. doi: 10.1016/j.berh.2019.101473.
8. A. E. Slingerland, Z. Schwabkey, D. H. Wiesnoski, and R. R. Jenq, “Clinical Evidence for the Microbiome in Inflammatory Diseases,” Frontiers in Immunology, vol. 8. Frontiers Media, Apr. 12, 2017. doi: 10.3389/fimmu.2017.00400.
9. L. Gao, T. Xu, G. Huang, S. Jiang, Y. Gu, and F. Chen, “Oral microbiomes: more and more importance in oral cavity and whole body,” Protein & Cell, vol. 9, no. 5. Springer Science+Business Media, p. 488, May 01, 2018. doi: 10.1007/s13238-018-0548-1.
10. Y. K. Opoku et al., “Intestinal microbiome–rheumatoid arthritis crosstalk: The therapeutic role of probiotics,” Frontiers in Microbiology, vol. 13. Frontiers Media, Oct. 18, 2022. doi: 10.3389/fmicb.2022.996031.
11. E. Roszyk and M. Puszczewicz, “Role of human microbiome and selected bacterial infections in the pathogenesis of rheumatoid arthritis,” Reumatologia/Rheumatology, vol. 55, no. 5. Termedia Publishing House, p. 242, Oct. 28, 2017. doi: 10.5114/reum.2017.71641.
12. Xalmetova, F. I., X. S. Akhmedov, and S. N. Buranova. "The Role of Imaging Techniques in the Assessment of Structural Changes in the Joint in Reactive Arthritis." Academicia Globe: Inderscience Research 3.03 (2022): 186-189.
13. Buranova S.N. Method of treatment aimed at the dynamics of cartilage oligomer matrix protein (COMP) in patients with osteoarthritis. // Turkish Journal of Physiotherapy and Rehabilitation; №32 (2) -P.4039-4041.
14. Abdurakhmanova, N., Akhmedov, K., Jabbarov, O., Rakhimova, M., Tagaeva, M., Khalmetova, F., & Tursunova, L. (2022). Clinical And Diagnostic Significance Of Anti-Cd74 In Patients With Ankylosing Spondylitis Of Uzbek Population.
15. Endothelin-1biomarker Features In Patients With Ankylosing Spondylitis After COVID-19. M Rakhimova, K Akhmedov, M Tagaeva, S Sadikova - Journal of positive school psychology, 2022
16. Khalmetova, F. I., Akhmedov, K. S., Buranova, S. N., Rakhimova, M. B., Rakhimov, S. S., & Abdurakhimova, L. A. (2023). Immunological Features of Reactive Arthritis of Various Etiologies. Journal of Coastal Life Medicine, 11, 1322-1325.
