TARGETING ADAMTS-7 METALLOPROTEINASE: A PROMISING APPROACH FOR MANAGING RHEUMATOID ARTHRITIS

Authors

  • Bekmirzaev A.E Author
  • Akhmedov Kh.S Author
  • Khalmetova F.I Author
  • Turayev I.A Author

Abstract

ADAMTS-7 is a promising molecular target for the diagnosis and treatment of rheumatoid arthritis. It plays an important role in the destruction of cartilage  in joint syndrome, especially in the active stage of the disease. Further clinical studies are needed to confirm its diagnostic and prognostic significance, as well as to develop targeted therapy aimed at inhibiting ADAMTS7 activity.

References

1. Bondeson J., et al. Role of synovial fibroblasts in RA pathogenesis. Arthritis Res Ther. 2006;8(3):223.

2. Buranova S. N. Akhmedov Kh. S., Razakova FS Cartilage oligomeric matrix protein (COMP) in early diagnosis of osteoarthritis //The Chinese Journal of Occupational Diseases of Labor and Health. – 2021. – Т. 7. – №. 39. – С. 93-100.

3. Buranova S. N. Akhmedov Kh. S., Razakova FS The Importance of Treatment Aimed at the Dynamics of Cartilage Oligomer Matrix Protein (COMP) in Patients with the Knee Joint Osteoarthritis //American Journal of Medicine and Medical Sciences.-2021. – Т. 11. – №. 2. – С. 148-153.

4. Gao G., et al. ADAMTS7 is associated with cartilage degradation in arthritis. J Biol Chem. 2004;279(6): 4273–4279.

5. Khalmetova F. I., Akhmedov K. S. Characteristics Of Articulate Syndrome In Patients With Reactive Arthritis.

6. Liu CJ. The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis. Nat Clin Pract Rheumatol. 2009;5(1):38–45.

7. Qin Y, Meng K, Han Y, et al. Therapeutic targeting of ADAMTS-7: A promising approach for arthritis treatment. Cell Biol Int. 2020;44(2): 333–342.

8. Rakhimova M. B. Impared endothelial dysfunction in covid-19: an overview of evidence, biomarkers in patients with ankylosing spondylitis //IMRAS. – 2023. – Т. 6. – №. 7. – С. 20-27.

9. Rakhimova M. et al. Endothelin-1biomarker Features In Patients With Ankylosing Spondylitis After COVID-19 //Journal of positive school psychology. – 2022. – С. 9369-9375.

10. Wang L., et al. ADAMTS-7 contributes to cartilage breakdown in rheumatoid arthritis. Arthritis Rheum. 2015;67(6):1548–1558.

11. Xalmetova F. I., Akhmedov X. S., Buranova S. N. The role of imaging techniques in the assessment of structural changes in the joint in reactive arthritis. – 2022.

12. Yang CY, Chanalaris A, Troeberg L. ADAMTS proteinases and osteoarthritis: Looking beyond the ‘usual suspects’. Osteoarthritis Cartilage. 2017;25(7):1000–1009.

13. Zhang L., et al. Targeting ADAMTS-7 in inflammatory arthritis. Cell Mol Immunol. 2020;17:262–274.

14. Абдурахимов А.Г., Халметова Ф.И. Нестероидные противовоспалительные препараты у пациентов с деформирующим остеоартрозом и артериальной гипертензией: анализ влияния целекоксиба и мелоксикама на антигипертензивные средства. Оптимизация лечения //Атеросклероз. – 2023. – Т. 19. – №. 3. – С. 186-187.

15. Nishanbayeva N. Y. Mirraximova MX Bolalarda atopik dermatitda oshqozon ichak traktidagi klinik laborator o ‘zgarishlarni aniqlash, tashxislash va davolash tamoyillarini takomillashtirish //Tibbiyotda yangi kun. – 2021. – Т. 6. – №. 38/1. 8.

16. Мirraximova M., Nishonboeva N. Genining polimorfizmi atopik dermatitda //Farg ‘ona davlat universiteti ilmiy jurnali. – 2023. – №. 1. – С. 162-165. 9.Nishanbayeva N. Y. et al. CAUSES OF ATOPIC DERMATITIS AND MEASURES FOR ITS PREVENTION //AMERICAN JOURNAL OF EDUCATION AND LEARNING. – 2025. – Т. 3. – №. 2. – С. 566-573.

17. Миррахимова М. Х., Нишанбаева Н. Ю. РОЛЬ TOLL-ПОДОБНЫХ РЕЦЕПТОРОВ В ПАТОГЕНЕЗЕ АТОПИЧЕСКОГО ДЕРМАТИТА //AMERICAN JOURNAL OF EDUCATION AND LEARNING. – 2024. – Т. 2. – №. 5. – С. 234-236.

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Published

2025-06-09