O‘PKANING SURUNKALI OBSTRUKTIV KASALLIGI BO‘LGAN BEMORLARDA N-ASETILSISTEINNING SAMARADORLIGINI META-TAHLIL ASOSIDA O‘RGANISH
Abstract
N-asetilsistein (NAC) antioksidant ta’siri orqali o‘pkaning surunkali obstruktiv kasalligi o‘tkir hurujini kamaytirishi mumkin. Tadqiqotlarning geterogenligi tufayli, hozirgi mavjud ma’lumotlar o‘pkaning surunkali obstruktiv kasalligi bo‘lgan bemorlarda og‘iz orqali NAC qabul qilish davolashning samaradorligini yetarlicha tasdiqlamaydi. O‘pkaning surunkali obstruktiv kasalligi bo‘lgan bemorlar muntazam ravishda og‘iz orqali NAC qabul qilishlari davolanishning yaxshi klinik natijalarini har doim ham bermaydi.
References
1. Dekhuijzen PN. Antioxidant properties of N-acetylcysteine: their relevance in relation to chronic obstructive pulmonary disease. Eur Respir J 2004; 23: 629–636. - PubMed
1. Sadowska AM, Manuel-Y-Keenoy B, De Backer WA. Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: discordant in vitro and in vivo dose-effects: a review. Pulm Pharmacol Ther 2007; 20: 9–22. - PubMed
1. Gul M, Kutay FZ, Temocin S, et al.. Cellular and clinical implications of glutathione. Indian J Exp Biol 2000; 38: 625–634. - PubMed
1. Drost EM, Skwarski KM, Sauleda J, et al.. Oxidative stress and airway inflammation in severe exacerbations of COPD. Thorax 2005; 60: 293–300. - PMC - PubMed
1. Domej W, Oettl K, Renner W. Oxidative stress and free radicals in COPD – implications and relevance for treatment. Int J Chron Obstruct Pulmon Dis 2024; 9: 1207–1224. - PMC - PubMed
