CLINICAL AND IMMUNOLOGICAL FEATURES OF NONRHEUMATIC CARDITIS IN CHILDREN
Abstract
The nonrheumatic carditis is considered to be an autoimmune disease, triggered by cardiotropic viruses in conditions of modified immune tolerance. The verification of different genetic markers to their possible association with nonrheumatic carditis, assessment of their significance in inbreed population, investigation of some instrumental values in probands of inbreed wedlock were the aims of current study. The obtained data will be useful as criteria of diagnosis in nonrheumatic carditis. 34 Uzbek children with nonrheumatic carditis, aged from 6 months to 14 years, born in inbreed wedlocks were studied. The ABO blood groups, PI and NH antigens, phenotypes of haptoglobin (HP) and of ceruloplasmin (CP), HLA antigens were studied as marker systems. The genetic features, typical of the high risk of nonrheumatic carditis in inbreed Uzbek population, realized in children with О (I) and A (II) blood group, but toxic-allergic forms with commonly developing cardiac complications - in children with В (III) and АВ (IV). Association of 2-1 haptoglobin complexes with A (II) blood group; 2-2 haptoglobin and I, IV groups; 2-2 haptoglobin and NH, PI complex, and especially with ceruloplasmin В increases the risk of nonrheumatic carditis development.
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