ASSOCIATION BETWEEN ADAMTS7 LEVELS, INFLAMMATORY MARKERS, AND STRUCTURAL JOINT CHANGES IN RHEUMATOID ARTHRITIS
Abstract
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent inflammation and progressive joint destruction. Identification of biomarkers reflecting both inflammatory activity and structural damage remains a key challenge. This study aimed to evaluate the association between ADAMTS7 levels, inflammatory markers, and structural joint changes in RA patients. A cross-sectional study included 46 patients aged 21–48 years, predominantly female, diagnosed according to ACR/EULAR criteria. Disease activity was assessed using DAS28. Serum levels of ADAMTS7, TNF-α, and IL-6 were measured by ELISA. Structural joint changes were evaluated using imaging methods. Elevated ADAMTS7 levels were observed in patients with higher disease activity. Significant positive correlations were found between ADAMTS7 and TNF-α, IL-6, as well as with structural joint damage. ADAMTS7 may serve as a promising biomarker reflecting both inflammation and joint destruction in RA.
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