CLINICAL PROGNOSTIC ASPECTS OF THE DEVELOPMENT OF REACTIVE ARTHRITIS: A LITERATURE REVIEW
Abstract
This article reviews the clinical prognostic aspects of the development of ReA, in particular, the potential role of the microRNA (miR)-146a molecule in the pathogenesis of the disease.. In recent years, the role of miR-146a in modulating the anti-inflammatory immune response has been widely studied in a number of rheumatic diseases, including rheumatoid arthritis and osteoarthritis. However, the direct relationship between miR-146a and ReA has not yet been sufficiently studied. This review covers literature published between 2020 and 2026, and attempts are made to extrapolate potential mechanisms in the pathogenesis of ReA through the role of miR-146a in other types of arthritis. The etiology, pathogenesis, clinical manifestations, and current treatment methods of the disease are also reviewed.
References
1. Abdullaev R.B., Rajapova Sh. Innovations in Technology and Science Education Vol. 1 No. 1 (2022). S. -5-6.
2. Akhmedov, K., Abdurakhmanova, N., & Buranova, S. (2023). Features of the clinical course of rheumatoid spice against the background of the influence of xenobiotics. American Journal of Interdisciplinary Research and Development, 12, 142-147.
3. Axmedov, I. A., Xalmetova, F. I., & Zaripov, S. I. (2024). Rematoid artrit kasalligi bo ‘lgan bemorlarda yurak qon-tomir tizimidagi buzulishlarni erta aniqlashda yurak ritmi buzilishlarining o ‘rni.
4. Buranova, S. (2021). Method of treatment aimed at the dynamics of cartilage oligomer matrix protein (COMP) in patients with osteoarthritis.
5. Cantorna, M.T. Vitamin D and autoimmunity: is vitamin D status an environmental factor affecting autoimmune disease prevalence? // Proc. Soc. Exp. Biol. Med. – 2000. – Vol. 223. – P. 230-233.
6. Cutolo, M. Vitamin D, immunity and lupus // M. Cutolo, K. Otsa // Lupus. – 2008. – Vol. 17. P. 6-10.
7. Induction of macrophage migration inhibitory factor in ConA-stimulated rheumatoid arthritis synovial fibroblasts through the P38 map kinasedependent signaling pathway // H.R. Kim, [et al.] // Korean. J. Intern. Med. – 2010. – Vol. 25. – P. 317–326.
8. Khalmetova, F. I., Akhmedov, K. S., Buranova, S. N., Rakhimova, M. B., Rakhimov, S. S., & Abdurakhimova, L. A. (2023). Immunological Features of Reactive Arthritis of Various Etiologies. Journal of Coastal Life Medicine, 11, 1322-1325.
9. Kiran, G. Vitamin D and rheumatoid arthritis: is there a link? / G. Kiran, D. // Debashish Int. J. Rheum. Dis. – 2008. – Vol. 11. – P. 206-211.
10. Lipsky PE, van der Heijde DM, St Clair EW, Furst DE, Breedveld FC, Kalden JR, et al.; Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group. Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-tumor necrosis factor trial in rheumatoid arthritis with concomitant therapy study group. N Engl J Med. 2000; 343(22):1594-1602.
11. Nasonov EL. Pharmacotherapy of rheumatoid arthritis: Russian and international recommendations. Scientific and practical rheumatology. 2016;54(5):557-571.
12. Rakhimova, M. B., Akhmedov, K. S., & Turaev, Y. A. (2021). Endothelial dysfunction as a link in the pathogenesis of ankylosing spondylitis against the background of a new coronavirus infection. ACADEMICIA: An International Multidisciplinary Research Journal, 11(3), 2493-2498.
13. Ramiro S. et al. Safety of synthetic and biological DMARDs: a systematic literature review informing the 2013 update of the EULAR recommendations for management of rheumatoid arthritis //Annals of the rheumatic diseases. – London, 2014. – С. 45-75.
14. Roux C. H. et al. Etanercept compared to intraarticular corticosteroid injection in rheumatoid arthritis: double-blind, randomized pilot study //The Journal of rheumatology. – Toronto, 2011. – Т. 38. – №. 6. – P. 1009-1011
15. Smolen JS, Landewé RBM, Bijlsma JWJ, Burmester GR, Dougados M, Kerschbaumer A, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update. Ann Rheum Dis. 2020;79(6):685-699.
16. Sparks JA. Rheumatoid arthritis. Ann Intern Med. 2019;170(1): ITC1-ITC16.
17. Sаchoels M. M. et al. Blocking the effects of interleukin-6 in rheumatoid arthritis and other inflammatory rheumatic diseases: systematic literature review and meta-analysis informing a consensus statement //Annals of the rheumatic diseases. – 2013. – Т. 72. – №. 4. – С. 583-589.
18. Tetlow, L.C. The effects of 1>,25-dihydroxyvitamin D3 on matrix metalloproteinase and prostaglandin E2 production by cells of the rheumatoid lesion / L.C. Tetlow, D.E. Wooley. // Arthritis Res. – 1999. – Vol. 1. – P. 63-70.
19. Van der Velde G. et al. Cost‐effectiveness of biologic response modifiers compared to disease‐modifying antirheumatic drugs for rheumatoid arthritis: A systematic review //Arthritis care & research. – Atlanta, 2011. – Т. 63. – №. 1. – P. 65-78.
20. Van Vollenhoven R. F. et al. Improvement in work place and household productivity for patients with early rheumatoid arthritis treated with adalimumab plus methotrexate: work outcomes and their correlations with clinical and radiographic measures from a randomized controlled trial companion study //Arthritis care & research. – Atlanta, 2010. – Т. 62. – №. 2. – P. 226-234.
21. Vitamin D receptorsin the rheumatoid lesion: expression by chondrocytes, macrophages, and synoviocytes / L.C. Tetlow [et al.] // Ann. Rheum. Dis. – 1999. – Vol. 58. – P. 118-121.
22. Wevers-de Boer K. et al. Remission induction therapy with methotrexate and prednisone in patients with early rheumatoid and undifferentiated arthritis (the IMPROVED study) //Annals of the rheumatic diseases. – London, 2012. – Т. 71. – №. 9. – P. 1472-1477.
23. Абдурахимов, А. Г., & Халметова, Ф. И. (2023). Нестероидные противовоспалительные препараты у пациентов с деформирующим остеоартрозом и артериальной гипертензией: анализ влияния целекоксиба и мелоксикама на антигипертензивные средства. Оптимизация лечения. Атеросклероз, 19(3), 186-187.
24. Рахимова, М. Б., Ахмедов, Х. С., & Халметова, Ф. И. (2025). ОЦЕНКА ЭНДОТЕЛИАЛЬНОЙ ДИСФУНКЦИИ У БОЛЬНЫХ РЕВМАТОИДНЫМ АРТРИТОМ.
25. Рахимова, М., Ахмедов, К., Буранова, С., и Турсунова, Л. (2022). Оценка сердечно-сосудистых событий у пациентов с анкилозирующим спондилитом после COVID-19.
26. Шовкатова, М. Н., & Рахимова, М. Б. (2025). ИСКУССТВЕННЫЙ ИНТЕЛЛЕКТ В ЦИФРОВОЙ СТРАТИФИКАЦИИ И ДИНАМИЧЕСКОМ КОНТРОЛЕ СЕРДЕЧНО-СОСУДИСТОГО РИСКА У БОЛЬНЫХ С АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИЕЙ И РЕВМАТОИДНЫМ АРТРИТОМ. FARS International Journal of Education, Social Science & Humanities., 13(12), 7-14.
