MODULATION OF CARDIOMARKER ENZYMES AND PHYSIOLOGICAL RESPONSES IN CARDIAC TISSUES USING PLANT EXTRACTS
Abstract
This article analyzes the modulatory effects of plant extracts on cardiomarker enzymes and the physiological responses of cardiac tissues. The discussion focuses on the behavior of key biomarkers—including troponins, creatine kinase (CK), and lactate dehydrogenase (LDH)—that reflect myocardial damage and stress. The review emphasizes the antioxidant, membrane-stabilizing, and anti-inflammatory properties of phytochemicals, highlighting their potential to modulate cellular signaling and preserve myocardial integrity. Dose-dependent effects, the support of energetic metabolism in cardiomyocytes, and the therapeutic prospects of plant-derived compounds in cardioprotection are also explored. The findings contribute to the development of biologically active, plant-based strategies for preventing and mitigating cardiac injury.
References
1. Ahmedov B. Biological activity of certain plant extracts from the flora of Uzbekistan and their pharmacological potential. Tashkent: Fan, 2019.
2. Bruker S., Robbers R., Tyler A. Pharmacognosy and Natural Product Research: Biological Activity of Medicinal Plants. London: Academic Press, 2012.
3. Chen M., Li Y., Wang S. Cardioprotective effects of herbal extracts on myocardial injury models: experimental analysis. Journal of Ethnopharmacology, 2020; 249: 112–119.
4. Dhalla A., Singh R. Molecular mechanisms of plant-derived cardioprotective agents. Heart Failure Reviews, 2018; 23(4): 567–579.
5. Frei B., Halliwell B., Ames B. Antioxidant mechanisms of plant polyphenols: implications for cardiovascular protection. PNAS, 1999; 96(4): 152–159.
6. Havsteen B. Flavonoids: a class of natural compounds with cardioprotective potential. Pharmacology & Therapeutics, 2002; 96(2): 67–75.
7. Li Y., Wang S. Herbal-derived antioxidants and their impact on cardiac enzymes in ischemic models. Phytotherapy Research, 2019; 33(7): 1805–1813.
8. Mavlonov Z. Antioxidant properties of local preparations developed from plant extracts. Samarkand: SamSU Press, 2021.
9. Middleton E., Kandaswami C., Theoharides T. The impact of flavonoids on inflammation and oxidative stress. Pharmacological Reviews, 2000; 52(4): 673–751.
10. Mitchell P. Natural antioxidants and mitochondrial stability: new perspectives. Biochemical Journal, 2015; 468(3): 345–356.
11. Mirzayeva G. Pharmacological characteristics and cardioprotective effects of local plant species. Bukhara: BSU Press, 2020.
12. Pietta P. Flavonoids as antioxidants: biochemical and medical properties. Journal of Natural Products, 2000; 63(8): 1035–1042.
13. Rice-Evans C., Miller N., Paganga G. Structure–antioxidant activity relationships of plant polyphenols. Free Radical Biology & Medicine, 1996; 20(7): 933–956.
14. Singh R., Dhalla N. Cardiomyocyte protection through modulation of oxidative pathways by phytochemicals. Cardiovascular Research, 2017; 113(3): 231–239.
15. Tyler V., Robbers R. Plant-derived bioactive compounds and their therapeutic value. New York: Springer, 2014.
16. Wang S., Chen M. Experimental evaluation of herbal extracts for mitochondrial protection. Journal of Medicinal Plants Research, 2018; 12(6): 101–109.
17. Xudoynazarov Sh. Bioactive compounds in plants and their effects on cardiac function. Tashkent: Innovative Medical Center, 2022.
18. Zohidov A. Cardioprotective properties of phytocomponents: theory and practice. Fergana: FSU Press, 2021.




















