DERMATOGLIFIK KO‘RSATKICHLARNING GENETIK VA KLINIK AHAMIYATI: KENGAYTIRILGAN MEDIKO-BIOLOGIK TAHLIL
Abstract
Ushbu kengaytirilgan tadqiqotda dermatoglifikaning embriologik shakllanishi, irsiy determinantlari, populyatsion farqlanishi va xromosoma sindromlaridagi klinik-diagnostik ahamiyati chuqur tahlil qilindi. Dermatoglifik naqshlarning (ark, loop, whorl) chastotasi, TRC (Total Ridge Count), ATD burchagi, palmar triradius indekslari kabi ko‘rsatkichlar asosida 200 nafar sog‘lom shaxs va 60 nafar xromosoma sindromlari (Down, Turner, Klinefelter) bo‘lgan bemorlar solishtirildi. Natijalar shuni ko‘rsatdiki, xromosoma patologiyalarida arch naqshlarining chastotasi keskin oshgan, TRC kamaygan va ATD burchagi sezilarli ravishda kengaygan. Dermatoglifika irsiy kasalliklarni erta aniqlash, risk guruhlarini shakllantirish va prenatal rivojlanishdagi buzilishlarni baholashda yuqori sezgir yordamchi marker bo‘lib xizmat qiladi.
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