FEATURES OF THE ROLE OF SEX HORMONES IN RHEUMATOID ARTHRITIS
Abstract
Rheumatoid arthritis (RA) is a chronic autoimmune disease, in the pathogenesis of which, in addition to immune disorders, hormonal and genetic mechanisms also play a key role. Sex hormones regulate the activity of the immune system and influence the course of the disease, and genetic variations determine individual sensitivity to hormonal signals and cytokines. The article presents a review of current data on the interaction of endocrine, genetic and epigenetic factors that determine clinical diversity and response to therapy in RA.
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