OIV-INFEKTSIYALI OʼTKIR DIАREYA BILАN KАSАLLАNGАN BOLАLАRDА OQSIL АLMАSHINUVI KOʼRSАTKICHLАRI.
Abstract
Asosiy guruhdagi bolalarda umumiy oqsil va albumin miqdorlari sog‘lom, 1- va 2-qiyosiy guruh bolalariga nisbatan past bo‘lib, bu ularning organizmida oqsil almashinuvining buzilganini va gipoproteinemiya rivojlanganini ko‘rsatadi. Ayniqsa alьbumin darajasining 2 barobar pasayishi (P<0,05) bu holatning klinik ahamiyatini tasdiqlaydi. α-1 globulin darajasi barcha guruhlarda bir xil bo‘lsa-da, ayrim holatlarda invaziv diareyalarda asosiy guruh bolalarida sezilarli pasayish (1,7 barobar, P<0,05) kuzatildi. α-2 globulin esa asosiy guruh bolalarda deyarli barcha holatlarda 1-qiyosiy guruhga nisbatan 2 barobar past (P<0,05) bo‘lib, bu oqsil sintezi jarayonlarining susayganini bildiradi. Asosiy guruhdagi bolalarda ß-globulin darajasi barcha qiyosiy guruhlarga nisbatan keskin past (3–8 barobar, P<0,001) aniqlangan. Bu esa organizmning immun va transport funksiyalarining susayganini ko‘rsatadi. Aksincha, γ-globulin miqdori asosiy guruhda yuqori bo‘lib, bu surunkali yoki uzoq davom etayotgan infektsion jarayonlarga javoban kompensator immun faollik ortishini bildiradi. Ayniqsa sekretor diareya bilan kasallangan bolalarda γ-globulin 1,7 barobar yuqori (P<0,05) bo‘lgani aniqlangan. O‘tkir diareya og‘irlashgan sari oqsil fraksiyalaridagi buzilishlar chuqurlashgan: α-2 va ß-globulinlar darajasi keskin kamaygan (P<0,05), γ-globulin esa yengil darajalarda oshgan, ammo og‘ir holatlarda barqarorlashgan. Bu holat immun tizimning kompensator javob mexanizmlari chegaralanganini ko‘rsatadi.
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