PHARMACOLOGICAL EFFECTS OF BIOACTIVE SUBSTANCES FROM THE ROOT OF EURYCOMA LONGIFOLIA ON THE HORMONAL SYSTEM.
Abstract
Eurycoma longifolia, commonly known as Tongkat Ali, is a medicinal plant widely recognized for its bioactive compounds that influence the hormonal system. This study explores the pharmacological effects of bioactive substances extracted from the root of Eurycoma longifolia, focusing on their impact on testosterone levels, stress-related hormones, and overall endocrine function. The research reviews mechanisms of action, clinical efficacy, and potential therapeutic applications in managing androgen deficiency, infertility, and metabolic disorders.
References
1. Tambi, M. I. B., Imran, M. K., & Henkel, R. R. (2012). Standardised water-soluble extract of Eurycoma longifolia improves testosterone levels in men and improves quality of life. Journal of the International Society of Sports Nutrition, 9(1), 15.
https://doi.org/10.1186/1550-2783-9-15
2. Chan, K., Othman, P., & Ismail, S. B. (2016). Eurycoma longifolia as a potential adaptogen for stress and testosterone regulation: A systematic review. Phytotherapy Research, 30(4), 626-636.
https://doi.org/10.1002/ptr.5561
3. Ismail, S. B., Wan Mohammad, W. M. Z., George, A., Nik Hussain, N. H., Musthapa Kamal, Z. M., & Liske, E. (2013). Randomized clinical trial on the use of Eurycoma longifolia for enhancing testosterone levels in aging males. Andrologia, 45(3), 154–161.
https://doi.org/10.1111/j.1439-0272.2012.01358.x
4. Talbott, S. M., Talbott, J. A., George, A., & Pugh, M. (2013). Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects. Journal of the International Society of Sports Nutrition, 10, 28.
https://doi.org/10.1186/1550-2783-10-28
5. Low, B. S., Choi, S. B., Wahab, H. A., Das, P. K., Chan, K. L. (2013). Eurycoma longifolia extract maintains bone mineral density and improves sexual performance in middle-aged male rats. Journal of Ethnopharmacology, 145(3), 706-714.
https://doi.org/10.1016/j.jep.2012.12.023
6. Henkel, R. R., Wang, R., Bassett, S. H., Chen, T., & Tambi, M. I. B. (2014). Eurycoma longifolia Jack: A review on its ethnopharmacology and clinical evidence. Phytomedicine, 21(7), 844–856.
