MODERN APPROACHES TO THE DIAGNOSIS, TREATMENT, AND PREVENTION OF MENINGOCOCCAL INFECTION: A LITERATURE REVIEW
Abstract
Background: Meningococcal infection, caused by Neisseria meningitidis, remains a significant global public health challenge characterised by rapid clinical progression, high case-fatality rates of 5–15%, and severe sequelae in survivors. Despite advances in vaccination and antimicrobial therapy, outbreaks continue to occur across all age groups and geographic regions, with a particularly high burden among infants and adolescents.
References
1. Nadel S, Ninis N. Invasive meningococcal disease in the vaccine era. Front Pediatr. 2021;9:615663. doi:10.3389/fped.2021.615663
2. Cohn AC, MacNeil JR, Harrison LH, Lynfield R, Reingold A, Schaffner W, et al. Changes in Neisseria meningitidis disease epidemiology in the United States, 1998–2020. Clin Infect Dis. 2021;73(4):e1098–e1107. doi:10.1093/cid/ciab149
3. WHO. Defeating meningitis by 2030: a global road map. Geneva: World Health Organization; 2021. Available from: https://www.who.int/docs/default-source/defeating-meningitis/meningitis-roadmap-2021.pdf
4. Muzzi A, Brozzi A, Serino L, Bodini M, Muzzi C, Martino A, et al. Genomic epidemiology and molecular characterization of Neisseria meningitidis serogroup W. J Infect. 2022;84(5):628–637. doi:10.1016/j.jinf.2022.01.023
5. Martinón-Torres F. Paediatric invasive meningococcal disease: an updated narrative review of the epidemiology and vaccine preventability. Infect Dis Ther. 2021;10(2):547–571. doi:10.1007/s40121-021-00427-x
6. Caforio M, Andreacchio C, Mardare M, Rocca DF, Penta L, Ceccoli M, et al. Hemodynamic monitoring and management of meningococcal septic shock: a single-center retrospective study. Front Pediatr. 2022;10:877804. doi:10.3389/fped.2022.877804
7. Brouwer MC, van de Beek D. Epidemiology, diagnosis, and treatment of bacterial meningitis. Curr Opin Infect Dis. 2021;34(3):202–208. doi:10.1097/QCO.0000000000000726
8. Vázquez JA, Marcos MÁ, Morales P, Cardeñoso L. Diagnosis of bacterial meningitis in the molecular biology era. Enferm Infecc Microbiol Clin. 2022;40(7):376–383. doi:10.1016/j.eimc.2021.11.009
9. Dogan H, Sayiner AA. Multiplex PCR panels for the diagnosis of central nervous system infections: clinical utility and laboratory perspectives. APMIS. 2023;131(3):83–94. doi:10.1111/apm.13283
10. Bratcher HB, Corton C, Jolley KA, Parkhill J, Maiden MC. Updated reference gene scheme for multilocus sequence typing of Neisseria meningitidis using whole-genome sequencing. J Clin Microbiol. 2021;59(8):e00360-21. doi:10.1128/JCM.00360-21
11. van de Beek D, Brouwer M, Hasbun R, Koedel U, Whitney CG, Wijdicks E. Community-acquired bacterial meningitis. Nat Rev Dis Primers. 2021;7(1):74. doi:10.1038/s41572-021-00310-2
12. Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, et al. Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021;47(11):1181–1247. doi:10.1007/s00134-021-06506-y
13. Christensen H, Trotter CL, Hickman M, Edmunds WJ. Re-evaluating cost effectiveness of universal meningitis vaccination (MenC) in England and Wales: modelling study. BMJ. 2022;377:e068897. doi:10.1136/bmj-2021-068897
14. Parikh SR, Andrews NJ, Beebeejaun K, Campbell H, Ribeiro S, Ward C, et al. Effectiveness and impact of a reduced infant schedule of 4CMenB vaccine against group B meningococcal disease in England: a national observational cohort study. Lancet. 2022;399(10332):1382–1391. doi:10.1016/S0140-6736(22)00168-6
15. CDC. Meningococcal vaccination: recommendations of the Advisory Committee on Immunization Practices, United States, 2020–2022. MMWR Recomm Rep. 2023;72(RR-1):1–49. doi:10.15585/mmwr.rr7201a1
16. ECDC. Invasive meningococcal disease annual epidemiological report for 2022. Stockholm: European Centre for Disease Prevention and Control; 2024. Available from: https://www.ecdc.europa.eu/en/publications-data/invasive-meningococcal-disease-annual-epidemiological-report-2022
17. Crum-Cianflone N, Sullivan E. Meningococcal vaccinations. Infect Dis Clin North Am. 2022;36(1):201–225. doi:10.1016/j.idc.2021.11.004




















