ASSESSMENT OF LACTATE DYNAMICS AND MICROCIRCULATION AS MARKERS OF INTENSIVE CARE EFFECTIVENESS IN SEPTIC SHOCK
Abstract
Septic shock remains one of the leading causes of mortality in intensive care units. Despite modern intensive care protocols, mortality associated with this condition remains high, necessitating the identification of reliable prognostic markers for treatment effectiveness.
References
1. Singer M., et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016.
2. Vincent J.L., et al. Sepsis in Intensive Care Units. Lancet. 2014.
3. Levy M.M., et al. Surviving Sepsis Campaign Guidelines. Critical Care Medicine. 2018.
4. Akalaev, R., Atahanov, S., Krasnenkova, M., Rosstalnaya, A., & Sabirov, D. (2014). Influence of different modes of mechanical ventilation on the development of acute lung injury in patients with severe combined traumatic brain injury: 5AP2-1. European Journal of Anaesthesiology, 31, 78.
5. Rhodes A., et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock. Intensive Care Medicine. 2017.
6. Hernandez G., et al. Early Lactate Clearance as a Determinant of Outcome. Critical Care. 2014.
7. Ramazanova Z., Ibragimov N. (2026). Modern approaches to the use of antioxidants in cerebral ischemia and traumatic brain injury. Central Asian Journal of Medicine, 1(8), 174-179. https://journals.tnmu.uz/index.php/cajm/article/view/3628
8. Jansen T.C., et al. Early Lactate-Guided Therapy in Intensive Care Unit Patients. American Journal of Respiratory and Critical Care Medicine. 2010.
9. Bakker J., et al. Blood Lactate Levels in Critically Ill Patients. Critical Care Clinics. 2016.
10. Singer M., et al. The Role of Microcirculatory Dysfunction in Sepsis. Critical Care. 2016.
11. De Backer D., et al. Microcirculatory Alterations in Sepsis. Intensive Care Medicine. 2011.
12. Vincent J.L., De Backer D. Microcirculatory Alterations in Septic Shock. New England Journal of Medicine. 2013.
