NEUROPROTECTION AND ANTIOXIDANT THERAPY IN THE COMPREHENSIVE MANAGEMENT OF TRAUMATIC BRAIN INJURY: IMPACT ON NEUROLOGICAL OUTCOMES AND OXIDATIVE STRESS
Abstract
Traumatic brain injury (TBI) remains one of the leading causes of disability and mortality among the working-age population. Oxidative stress, inflammation, and neuronal dysfunction play a crucial role in the pathogenesis of secondary brain injury. The aim of this study was to evaluate the effectiveness of neuroprotective and antioxidant therapy in the comprehensive treatment of patients with TBI. An analysis of current literature and clinical observations concerning the effects of antioxidants on the severity of oxidative stress, neurological status, and functional outcomes was conducted. It was found that the use of neuroprotective agents with antioxidant properties contributes to reducing neuronal damage, decreasing the intensity of free radical oxidation, and improving the recovery of neurological functions. The obtained data confirm the potential value of neuroprotective and antioxidant strategies in the comprehensive management of traumatic brain injury.
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