RECENT ADVANCES IN THE DIAGNOSIS AND TREATMENT OF HEPATITIS B VIRUS INFECTION
Abstract
Hepatitis B and C viruses (HBV and HCV) are the primary causes of end-stage liver disease—liver failure and cirrhosis—worldwide. Although an effective vaccine against HBV exists, many new cases of infection are reported annually, particularly in resource-limited regions with weak vaccination policies. Furthermore, since there is no cure for HBV and chronic infection is lifelong, vaccines cannot treat individuals who are already infected. Research focused on an in-depth study of HBV biology and pathogenesis is limited, and much remains unknown about its genetic characteristics and their role in establishing and maintaining infection. The impact of these characteristics on disease progression and treatment response, especially in areas with a high prevalence of the virus, has not been fully explored. This underscores the need for in-depth research into the virus's biology, primarily to develop better management strategies for infected individuals and create effective prevention measures for others. Such information could also pave the way for finding a cure. In this article, we discuss the progress made in understanding the genetic basis of viral activity, which determines the complex interaction between the virus and the host, and the effects of co-infections.
References
1. Axmedov, A. A., Karimov, M. M., & Rasulov, H. R. (2019). Yuqumli kasalliklar (pp. 1–420). Toshkent: Abu Ali ibn Sino nashriyoti.
2. Abdullayev, B. T., & Tursunov, O. S. (2020). Virusli gepatitlar klinikasi va davolash usullari (pp. 15–210). Toshkent: Tibbiyot nashriyoti.
3. Xolmatov, B. X., & Ahmedov, K. A. (2021). Jigar kasalliklari diagnostikasi va profilaktikasi (pp. 25–260). Toshkent: Ilm Ziyo.
4. Rasulova, N. R., & Ismoilov, A. I. (2019). Virusologiya asoslari (pp. 1–350). Toshkent: Fan va texnologiya.
5. Rahmonov, D. Sh., & Qodirov, Sh. A. (2018). Yuqumli kasalliklar epidemiologiyasi (pp. 40–310). Toshkent: Tibbiyot akademiyasi nashriyoti.
6. Karimova, M. S., & To‘xtayev, R. B. (2022). Jigar kasalliklari patogenezi (pp. 10–280). Toshkent: Yangi nashr.
7. Abdurahmonov, A. A., & Yusupov, F. F. (2020). Tibbiy immunologiya asoslari (pp. 1–330). Toshkent: O‘zbekiston milliy universiteti nashriyoti.
8. Turg‘unov, H. N., & Mahmudov, O. O. (2021). Gepatit B infeksiyasining klinik xususiyatlari (pp. 35–190). Toshkent: Tibbiyot.
9. Qosimov, B. K., & Mirzayev, Z. A. (2019). Tibbiyotda laborator diagnostika (pp. 1–270). Toshkent: Akademnashr.
10. Karimov, S. T., & Raxmatullayev, N. M. (2023). Virusli gepatitlarning zamonaviy diagnostikasi (pp. 60–220). Toshkent: Tibbiyot akademiyasi nashriyoti.
11. Sodiqov, B. A., & Yo‘ldoshev, D. Q. (2018). Tibbiy biologiya (pp. 1–300). Toshkent: Fan.
12. Iskandarov, M. H., & Tashpulatov, A. A. (2020). Tibbiy mikrobiologiya va virusologiya (pp. 1–410). Toshkent: Ilm Ziyo.
13. Rasulov, Sh. S., & Rahimova, D. T. (2021). Jigar kasalliklari terapiyasi (pp. 20–240). Toshkent: Tibbiyot.
14. Karimov, B. R., & Shodmonov, F. N. (2019). Tibbiy epidemiologiya asoslari (pp. 1–290). Toshkent: Fan va texnologiya.
15. O‘zbekiston Respublikasi Sog‘liqni saqlash vazirligi. (2022). Virusli gepatitlar bo‘yicha klinik tavsiyalar (pp. 1–120). Toshkent.
16. Abdullayev, S. R., & Xudoyberdiyev, M. K. (2021). Gepatit B va C infeksiyalarining tarqalishi va profilaktikasi (pp. 30–150). Toshkent: Tibbiyot.
17. Mamatqulov, O. J., & Jo‘rayev, A. B. (2020). Yuqumli kasalliklar klinikasi (pp. 1–360). Toshkent: Akademnashr.
18. Максумова, Н. Б., Ниязметов, Р. Э., Матякубов, Б. Б., & Усинова, З. Б. (2019). РОЛЬ МЕСТНОГО ИСПОЛЬЗОВАНИЯ КОНЪЮГИРОВАННОГО ЭСТРОГЕНА В УЛУЧШЕНИИ ИСХОДОВ ОПЕРАТИВНОГО ЛЕЧЕНИЯ ПРОЛАПСА ГЕНИТАЛИЙ. Innova, (2 (15)), 20-23.
19. Назаров, Б. Б., Усинова, З. Б., & Ниязметов, Р. Э. (2020). РОЛЬ МЕСТНОГО ИСПОЛЬЗОВАНИЯ КОНЪЮГИРОВАННОГО ЭСТРОГЕНА В УЛУЧШЕНИИ ИСХОДОВ ОПЕРАТИВНОГО ЛЕЧЕНИЯ ПРОЛАПСА ГЕНИТАЛИЙ. Новый день в медицине, (2), 446-448.
20. NIYAZMETOV, R., MATYAKUBOV, B., NAZAROV, B., & USINOVA, Z. MASSIVE OBSTETRIC BLEEDING: OPTIMIZATION OF TOTAL HYSTERECTOMY SURGERY TECHNIQUE AND CONSERVATIVE TREATMENT. INFUSION & CHEMOTHERAPY Учредители: Communicable Diseases Intensive Care Association, (3.1), 55-56.
21. Sadullayev, S. E., Artikova, D. O., & Sadullayeva, M. R. (2026, January). STRENGTHENING CLINICAL REASONING IN INFECTIOUS DISEASES. In Scottish International Conference on Multidisciplinary Research and Innovation–SICMRI 2025 (Vol. 3, No. 1, pp. 19-21).
22. Khusanov, A. M., Kh, N. A., & Sadullaev, S. E. (2024). THE STRUCTURE OF COMORBID PATHOLOGY IN CHILDREN WITH COVID-19. In CONFERENCE ON THE ROLE AND IMPORTANCE OF SCIENCE IN THE MODERN WORLD (Vol. 1, No. 2, pp. 27-28).
23. Sadullaev, S. E., Ibragimov, S. J., Bobojonov, Y. B., Yoqubov, Q. Y., Abdullayeva, D. K., & Khasanova, J. R. (2024). PREVALENCE OF DIARRHEAL DISEASES IN THE REPUBLIC OF UZBEKISTAN. International Journal of Education, Social Science & Humanities, 12(3), 356-363.
24. Raxmonova, L. M., & Usmonov, D. T. (2023). Jigar kasalliklarida laborator tekshiruvlar (pp. 15–200). Toshkent: Yangi asr avlodi.
25. Saidov, N. S., & Abduqodirov, F. T. (2019). Virusli infeksiyalar epidemiologiyasi (pp. 1–280). Toshkent: Tibbiyot nashriyoti.
26. Mirzayev, O. R., & Qosimova, Z. A. (2020). Infeksion kasalliklar diagnostikasi (pp. 1–300). Toshkent: Ilm Ziyo.
27. Yusupova, N. F., & Mamatov, S. H. (2024). Gepatit infeksiyalarining zamonaviy davolash usullari (pp. 25–160). Toshkent: Tibbiyot akademiyasi nashriyoti.
28. Abdullayev, K. T., & Rahmonova, M. A. (2022). Virusli gepatitlarning profilaktikasi (pp. 10–140). Toshkent: Fan.
29. Jo‘rayev, D. Q., & Usmonova, S. B. (2023). Yuqumli kasalliklar nazariyasi (pp. 1–310). Toshkent: Yangi asr avlodi.
