IMMUNOHISTOCHEMICAL ANALYSIS OF THE PROLIFERATIVE ACTIVITY OF KI-67 IN LICHEN PLANUS OF THE ORAL MUCOSA
Abstract
Lichen planus is a chronic inflammatory disease of the skin and mucous membrane of the oral cavity (SOPR), characterized by the appearance of papules on the skin and mucous membrane of the oral cavity and accompanied by itching. In the general structure of dermatological morbidity, the lesion of the skin is 2.5%, and the oral mucosa is 35%. [2,3,4,13]. Morphological elements of CPL can sometimes precede the appearance of skin rashes or may remain the only sign of the disease. When the SOPR is affected, 62-67% of patients are women aged 40-60 years. Modern literature sources [1,15,18] indicate the significant role of various general and local factors in the etiology of lichen planus: anxiety, stress and depressive disorders, medications, human papillomavirus, Epstein―Barr, human herpes, human immunodeficiency virus (HIV), hepatitis B and C, microorganisms (Helicobarter pylori, Candida albicans), periodontal pathogens [5,6,8,19]. Local adverse factors of the oral cavity, such as poor oral hygiene, hyposalivation, and dental row defects, play a major role in the pathogenesis of CPL and the aggravation of its course. CPL is a multifactorial polyethological disease, in the development of which immunological, neuroendocrine, intoxication and metabolic factors are important [7,20,14,17]. There are several theories of the development of CPL: viral (infectious), hereditary, immunological, neurogenic, endocrine and metabolic disorders, traumatic, autoimmune, medications, and others.
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