MICROBIAL AND VIRAL FACTORS IN THE ETIOPATHOGENESIS OF APICAL PERIODONTITIS: A SYSTEMATIC REVIEW OF APICAL ROOT CANAL MICROBIOME AND HERPESVIRUS ASSOCIATIONS
Abstract
Background: Apical periodontitis is a polymicrobial inflammatory disease primarily associated with infection of the root canal system. Recent advances in molecular microbiology have improved understanding of bacterial communities in the apical root canal segment, while viral agents such as human cytomegalovirus (HCMV) and Epstein–Barr virus (EBV) have been proposed as potential cofactors in periapical lesion pathogenesis.
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