COMPARISON OF BIOCHEMICAL AND HEMATOLOGICAL PARAMETERS IN GROUPS TREATED WITH CURCUMIN AND GINGER EXTRACTS AGAINST DIABETES
Abstract
The aim of this study was to evaluate the effects of curcumin and ginger extracts on biochemical and hematological parameters under experimental diabetes mellitus (DM) conditions. In the study, animals with diabetes induced by streptozotocin were divided into four groups: control group, diabetes (DM) group, DM + curcumin group, and DM + ginger extract group. After 28 days of treatment with the phytobiologically active substances, biochemical parameters such as glucose, glycated hemoglobin (HbA1c), total protein, ALT, AST, triglycerides, and total cholesterol, as well as hematological parameters including erythrocyte count, hemoglobin level, leukocyte, and platelet counts were assessed. The results showed that curcumin and ginger extracts effectively reduced glucose levels, normalized liver transaminases, and enhanced antioxidant activity, significantly improving diabetes-associated hematological disorders. In particular, the curcumin-treated group demonstrated a greater reduction in HbA1c and normalization of hematological indices. The obtained results confirm that curcumin and ginger may exert antioxidative, hepatoprotective, and hematopoietic effects in the pathogenesis of diabetes mellitus.
References
1. American Diabetes Association. Standards of Medical Care in Diabetes — 2024. Diabetes Care. 2024;47(Suppl 1):S1–S321.
2. International Diabetes Federation. IDF Diabetes Atlas, 10th edition. Brussels: International Diabetes Federation; 2021.
3. World Health Organization. Global report on diabetes. Geneva: WHO; 2022.
4. Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol. 2009;41(1):40–59.
5. Panahi Y, Hosseini MS, Khalili N, et al. Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome: A post-hoc analysis of a randomized controlled trial. Biomed Pharmacother. 2016;82:578–582.
6. Na LX, Zhang YL, Li Y, et al. Curcumin improves insulin resistance in skeletal muscle of rats induced by high-fat diet via IRS-1/PI3K/Akt signaling pathway. Biomed Res Int. 2019;2019:1–10.
7. Al‐Amin ZM, Thomson M, Al‐Qattan KK, et al. Anti-diabetic and hypolipidemic properties of ginger (Zingiber officinale) in streptozotocin-induced diabetic rats. Br J Nutr. 2006;96(4):660–666.
8. Morakinyo AO, Akinola OB, Adeniyi OS. Antidiabetic and antihyperlipidemic effects of aqueous extract of ginger (Zingiber officinale) on experimentally induced-diabetic rats. J Med Plants Res. 2011;5(14):3053–3057.
9. Daily JW, Yang M, Park S. Efficacy of ginger for treating Type 2 diabetes: A systematic review and meta-analysis of randomized clinical trials. J Ethnopharmacol. 2015;175:532–543.
10. Ebrahimzadeh Attari V, Malek Mahdavi A, Jafari S, et al. A systematic review of the anti-diabetic effects of ginger. Eur J Clin Nutr. 2021;75:709–717.
11. Srinivasan K. Ginger rhizomes as a spice with multiple health-improving properties. Phytother Res. 2017;31(3):403–406.
12. He HJ, Wang G, Gao Y, et al. Curcumin attenuates oxidative stress and inflammation in diabetic nephropathy via Sirt1–FoxO1 signaling pathway. Mol Med Rep. 2020;22(6):5059–5068.
13. Derosa G, Maffioli P. Anti-inflammatory benefits of curcumin in the metabolic syndrome. Nutrients. 2020;12(1):1–16.
14. Sahebkar A. Curcumin: a natural multitarget modulator. J Nutr Sci. 2021;10:e15.
15. Liju VB, Jeena K, Kuttan R. An evaluation of antioxidant, anti-inflammatory and antinociceptive activities of essential oil from Zingiber officinale. Indian J Biochem Biophys. 2015;52:72–78.
