HYPOMYELINATING LEUKODYSTROPHIES IN INFANCY: CLINICAL PROGRESSION, NEUROIMAGING CORRELATES, AND THERAPEUTIC IMPLICATIONS"
Abstract
This article examines 12 cases of severe neuroprogressive disorders described by Chattha and Richardson, characterized by disrupted myelination and spastic quadriparesis with onset in early infancy. We analyze the clinical progression, neuropathological findings (notably profound cerebral hypomyelination without inflammatory/destructive processes), and evidence for genetic etiology. Nutritional influences on myelination (iron, zinc, LCPUFA deficiencies) and parallels with Lyon’s axonal development disorders are discussed.
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