HELICOBACTER PYLORI AND HOST BGENE POLYMORPHISM TNF RS1800629 IN CHILDREN WITH GASTRODUODENAL PATHOLOGY
Abstract
Relevance. The immune response to H. pylori infection in children is an earlier pathological response and can serve as a kind of model for studying the characteristic course of H. pylori. In the conditions of the Republic of Uzbekistan, such studies have not been carried out, at the same time, the tendency towards weight gain, rejuvenation and a high frequency of complications dictate the need to study this issue. Purpose of the study. To study the clinical and prognostic significance of the rs1800629 (G308A) polymorphism of the TNF gene in children with gastroduodenal pathology, depending on H. pylori infection. Patients and methods. Examined 182 children aged 7 to 18 years with gastroduodenal pathology. Of these, 98 (53.8%) patients with HP associated pathology and 84 (46.2%) patients with HP negative pathology of the gastroduodenal zone. The rs1800629 (G-308A) polymorphism of the TNF gene was determined. Statistical data processing has been carried out. Results. The presence of the GA TNF-a genotype rs1800629 is an unfavorable prognostic marker in the development of this pathology in the presence of HP infection. At the same time, the GG genotype rs1800629 is a protective genotype for the underlying pathology, regardless of the presence of HP infection. Conclusion. The presence of the GA genotype TNF-a rs1800629 is an unfavorable prognostic marker in the development of this pathology in the presence of HP infection. GG genotype rs1800629 is a protective genotype for the underlying pathology, regardless of the presence of HP infection.
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