EARLY DIAGNOSTICS OF ONCOLOGICAL DISEASES IN THE EXAMPLE OF MULTIPLE MYELOMA: MODERN TECHNOLOGIES
Abstract
In modern times, where oncological diseases are prevalent in this fast-paced society and thus forming a great challenge to healthcare settings, a very common form of such malignancy is Multiple myeloma affecting millions of individuals. It is a type of plasma cell clonal proliferative disorder that predominately affects the bone. Other systemic complications such as anemia, renal dysfunction, lytic lesions in bone, and immunosuppression. Misdiagnosis or diagnosis at an advanced-stage is very common scenario due to the insidious onset as a result of the nonspecific nature of its symptoms. The emphasis of this study is on early diagnosis by combining clinical assessment, laboratory markers such as serum protein electrophoresis, immunofixation, and free light chain assay, advanced imaging modalities including MRI, PET-CT, and low-dose
whole-body CT. Thus, better prognosis due to early diagnosis by new biomarkers and genetic profiling is attributed to timely initiation of targeted therapies, lesser complications, and improved overall survival rates and quality of life.
References
1. Robbin’s and Cotran pathologic basis of diseases, Kumar Abbas Aster, 11e: 1179-1213.
2. Textbook of radiology and imaging, David Sutton, Bharat Aggarwal, 8e:1287-1307.
3. Textbook of radiology for X-ray, BSC and MSC technicians ,Sachin khanduri ,2e
4. Textbook of Imaging modalities and recent advances in Diagnostic Radiology, Dinesh K Baghel: 42-121p.
5. Harrison’s principles of internal medicine, 21e : 653-657.
6. Exam Preparatory manual for undergraduates pathology, Ramdas Nayak, Rakshita Nayak ,4e:742-762.
7. Davidson’s principles and practice of Medicine, editor:Ian D. Penman, Stuart H Ralston, Mark W. J. Strachan:561-605.
8. Multiple myeloma and other plasma cell neoplasms, Springer, Meletios A. Dimopoulos, Thierry Facon, Evangelos Terpos.
9. Plasma cell neoplasms pathogenesis diagnosis and laboratory evolution by Robert B Lorsbach, Marwan Yared.
10. Hematology/ Oncology Clinics of North America, Kenneth C. Anderson, vol21.
